Persistent organic pollutants alter DNA methylation during human adipocyte differentiation
نویسندگان
چکیده
منابع مشابه
Persistent Organic Pollutants ("POPs")
Strictly speaking, all toxins entering the environment can be regarded as environmental poisons. Certain pollutants can, acting over long periods, harm living organisms even in low concentrations. This means that pollutants that are stable and thus persistent have a great ability to act as environmental poisons. Their stability means not only that their effects are long-lasting, but also that t...
متن کاملSerum Persistent Organic Pollutants
Persistent organic pollutants (POPs) are manmade organic chemicals that remain in the environment for years or decades. POPs are of special concern because they often remain toxic for decades or longer after release to the environment. The more persistent a toxic chemical is, the greater the probability for human exposure over time. Because they circulate globally long after being released into...
متن کاملEffects of age, sex, and persistent organic pollutants on DNA methylation in children.
Epigenetic changes such as DNA methylation may be a molecular mechanism through which environmental exposures affect health. Methylation of Alu and long interspersed nucleotide elements (LINE-1) is a well-established measure of DNA methylation often used in epidemiologic studies. Yet, few studies have examined the effects of host factors on LINE-1 and Alu methylation in children. We characteriz...
متن کاملChapter 8 Persistent Organic Pollutants
The rapid growth in chemical and agrochemical industries during the last century have resulted in the environmental releases of a large number of new chemical compounds into the environment. According to the OECD, the daily use of chemicals includes about 70,000 mainly organic synthetic chemicals, and the number increases continuously (Schwarzenbach et al. 1993). Over the last decades, there ha...
متن کاملTransport of persistent organic pollutants across the human placenta.
Prenatal life is the most sensitive stage of human development to environmental pollutants. Early exposure to persistent organic pollutants (POPs) may increase the risk of adverse health effects during childhood. The mechanisms of transference of POPs during pregnancy are still not well understood. The present study is aimed to investigate the transfer of POPs between mother and fetus. The conc...
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ژورنال
عنوان ژورنال: Toxicology in Vitro
سال: 2017
ISSN: 0887-2333
DOI: 10.1016/j.tiv.2016.12.011